4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime
AP-18
CAS: 55224-94-7
Molecular Formula: C11H12ClNO
4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime - Names and Identifiers
4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime - Physico-chemical Properties
| Molecular Formula | C11H12ClNO |
| Molar Mass | 209.67 |
| Solubility | DMSO: >10mg/mL |
| Appearance | solid |
| Color | white to off-white |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| In vitro study | At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca 2+ imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes . |
| In vivo study | AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity. |
4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime - References
| biological activity | AP-18 is a selective TRPA1 inhibitor that blocks the activation of TRPA1 by 50 μm cinnamaldehyde AP-18, the IC50 values in human and mouse were 3.1 μm and 4.5 μm, respectively. AP-18 reversal of CFA-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μm AITC-induced Yo-Pro uptake in a concentration-dependent manner with an IC50 of 10.3 μm. |
Last Update：2024-04-09 21:54:55
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Product Name: AP-18 Visit Supplier Webpage Request for quotation
CAS: 55224-94-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 55224-94-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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